download manual do receptor century br 2014

In the CNS, A 1 receptors are widely distributed in the cortex, hippocampus, and cerebellum, A 2A receptors are localized mainly in the striatum and olfactory bulb, while A 2B and A 3 receptors are found at low levels of expression. In terms of molecular pathways and second messengers involved, A 1 and A 3 receptors inhibit adenylyl cyclase (AC), through G i/o proteins, while A 2A and A 2B receptors stimulate it through G s proteins. In particular, in the central nervous system (CNS), adenosine acts as a neuromodulator, exerting different functions depending on the type of AR and consequent cellular signaling involved. To date, they are known to participate in a large variety of physiopathological responses, which include vasodilation, pain, and inflammation.

3Department of Medical Sciences, Pharmacology Section, University of Ferrara, Ferrara, ItalyĪdenosine receptors (AR) are a family of G-protein coupled receptors, comprised of four members, named A 1, A 2A, A 2B, and A 3 receptors, found widely distributed in almost all human body tissues and organs.

2Department of Nursing, Physiotherapy and Occupational Therapy, School of Nursing and Physiotherapy, University of Castilla-La Mancha, Toledo, Spain.

1Department of Inorganic and Organic Chemistry and Biochemistry, School of Medicine, University of Castilla-La Mancha, Ciudad Real, Spain.

Castillo 2*, Stefania Merighi 3* and Stefania Gessi 3 Inmaculada Ballesteros-Yáñez 1, Carlos A.

Download manual do receptor century br 2014